Introduction : the state of the planet Earth : time to 'stop and think'! -- Part I. Safeguarding the health and well-being of people and planet -- Threats to the health and sustainability of populations -- Climate change : focus on Africa, Asia, and the coastal poor -- The fourth industrial revolution and the 'intelligence era' -- Planetary health and the incongruity of modernity -- Capitalism with a social conscience -- Part II. Reflections on a changing world order -- War and Peace? -- The world in 2050 : megatrends and social impacts -- Reorienting society towards a sustainable future -- One Health and well-being : inspiring a 'global unity of purpose' -- Part III. Creating a 'more just, sustainable and peaceful world' -- Global education : building foundations for the future -- Collaborative One Health and well-being initiatives -- Leading in an era of uncertainty, upheaval and anxiety -- The promise of Generation Z -- Epilogue : homo deus or homo humilem? The choice is ours.